PREACT

Langhammer, T., Unterfeld, C., Blankenburg, F., Erk, S., Fehm, L., Haynes, J.-D., Heinzel, S., Hilbert, K., Jacobi, F., Kathmann, N., Knaevelsrud, C., Renneberg, B., Ritter, K., Stenzel, N., Walter, H., & Lueken, U. (2025). Design and methods of the research unit 5187 PREACT (towards precision psychotherapy for non-respondent patients: From signatures to predictions to clinical utility) – a study protocol for a multicentre observational study in outpatient clinics. BMJ Open, 15(2), e094110. https://doi.org/10.1136/bmjopen-2024-094110

Hilbert, K., Böhnlein, J., Meinke, C., Chavanne, A. V., Langhammer, T., Stumpe, L., Winter, N., Leenings, R., Adolph, D., Arolt, V., Bischoff, S., Cwik, J. C., Deckert, J., Domschke, K., Fydrich, T., Gathmann, B., Hamm, A. O., Heinig, I., Herrmann, M. J., … Lueken, U. (2024). Lack of evidence for predictive utility from resting state fMRI data for individual exposure-based cognitive behavioral therapy outcomes: A machine learning study in two large multi-site samples in anxiety disorders. NeuroImage, 295, 120639. https://doi.org/10.1016/j.neuroimage.2024.120639

Hilbert, K., Weller, P., Ritter, K., Haynes, J.-D., Walter, H., & Lueken, U. (2024). Design studies for clinical prediction. Science, 385(6709), 613–613. https://doi.org/10.1126/science.adp1063

Meinke, C., Lueken, U., Walter, H., & Hilbert, K. (2024). Predicting treatment outcome based on resting-state functional connectivity in internalizing mental disorders: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 160, 105640. https://doi.org/10.1016/j.neubiorev.2024.105640

Meinke, C., Hornstein, S., Schmidt, J., Arolt, V., Dannlowski, U., Deckert, J., Domschke, K., Fehm, L., Fydrich, T., Gerlach, A. L., Hamm, A. O., Heinig, I., Hoyer, J., Kircher, T., Koelkebeck, K., Lang, T., Margraf, J., Neudeck, P., Pauli, P., … Hilbert, K. (2024). Advancing the personalized advantage index (PAI): A systematic review and application in two large multi-site samples in anxiety disorders. Psychological Medicine, 54(16), 4843–4855. https://doi.org/10.1017/S0033291724003118

Jüres, F., Kaufmann, C., Riesel, A., Grützmann, R., Heinzel, S., Elsner, B., Bey, K., Wagner, M., Kathmann, N., & Klawohn, J. (2024). Heart rate and heart rate variability in obsessive-compulsive disorder: Evidence from patients and unaffected first-degree relatives. Biological Psychology, 189, 108786. https://doi.org/10.1016/j.biopsycho.2024.108786

Torbecke, J., Langhammer, T., Mewes, L., Lueken, U., & Fendel, J. C. (2024). Augmentation of cognitive-behavioural therapy for obsessive-compulsive and anxiety disorders: A protocol for a systematic review and meta-analysis. BMJ Open, 14(10), e090431. https://doi.org/10.1136/bmjopen-2024-090431

Hammelrath, L., Hilbert, K., Heinrich, M., Zagorscak, P., & Knaevelsrud, C. (2024). Select or adjust? How information from early treatment stages boosts the prediction of non-response in internet-based depression treatment. Psychological Medicine, 54(8), 1641–1650. https://doi.org/10.1017/S0033291723003537

Jüres, F., Wewers, R., Hajcak, G., Kathmann, N., & Klawohn, J. (2024, 11.-15. Juni). Understanding Feedback Processing in Reward Tasks: A Comparison of Electrophysiological Correlates (RewP and P300) Across Two Paradigms [Posterpräsentation]. 3. Deutscher Psychotherapie Kongress, Berlin, Deutschland.

Jüres, F., Wewers, R., Hajcak, G., Kathmann, N., & Klawohn, J. (2024, 28. Mai-1. Juni). Neural correlates of feedback processing in internalizing disorders: A comparison of guessing and learning scenarios [Posterpräsentation]. The 49th Annual Meeting of Psychologie und Gehirn, Hamburg, Deutschland.

Sprengel, R., & Klawohn, J. (2024, 9. Oktober). Studying emotion regulation and inhibition in emotionally unstable personality disorder with psychophysiology—STEPS study protocol [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Wellan, S., Daniels, A., Schnell, Kruschwitz, J. D., & Walter, H. (2024, 10.-13. Juli). Neural correlates of meaning in life in resting-state fMRI [Posterpräsentation]. ECPP2024, Innsbruck, Österreich.

Wellan, S., Daniels, A., & Walter, H. (2024, 10.-13. Juli). Associations of hedonic and eudaimonic motives for activities with mental health and life satisfaction. A longitudinal survey study [Posterpräsentation]. ECPP2024, Innsbruck, Österreich.

Wellan, S., Daniels, A., & Walter, H. (2024, 25. September). Facets of Anhedonia. Differentiating anticipatory pleasure, consummatory pleasure and hedonic domains as prospective resilience factors [Posterpräsentation]. DZPG Annual Conference, Berlin, Deutschland.

Wellan, S., Heinzel, S., & Walter, H. (2024, 9. Oktober). Predicting mental health symptoms with NBS-Predict [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Wewers, R., Jüres, F., Kathmann, N., & Klawohn, J. (2024, 11. Juni). Electrophysiological measures of emotional reactivity and emotion regulation in patients & healthy controls [Posterpräsentation]. 3. Deutscher Psychotherapie Kongress, Berlin, Deutschland.

Wewers, R., Jüres, F., Kathmann, N., & Klawohn, J. (2024, 29. Juni). Electrophysiological measures of emotional reactivity and emotion regulation in patients & healthy controls [Posterpräsentation]. The 49th Annual Meeting of Psychologie und Gehirn, Hamburg, Deutschland.

Wyka, S., Fehm, L., Jacobi, F., Kathmann, N., Lueken, U., Renneberg, B., Langhammer, T., Fliedner, L., Künstler, A., Sauder, T., Unterfeld, C., & Stenzel, N. (2024, 16.-19. September). Illness Perceptions (IP) – ein unterschätzter Faktor bei internalisierenden Störungen [Posterpräsentation]. 53rd Congress of the German Psychological, Wien, Österreich.

Wyka, S., Fehm, L., Jacobi, F., Kathmann, N., Lueken, U., Renneberg, B., Langhammer, T., Fliedner, L., Künstler, A., Sauder, T., Unterfeld, C., & Stenzel, N. (2024, 11.-15. Juni). Illness Perception Questionnaire—Mental Health (IPQ-MH): Ein neues ökonomisches Selbstbeurteilungsinstrument mit guten psychometrischen Eigenschaften [Posterpräsentation]. 3. Deutscher Psychotherapie Kongress, Berlin, Deutschland.

Wyka, S., Fehm, L., Jacobi, F., Kathmann, N., Lueken, U., Renneberg, B., Langhammer, T., Fliedner, L., Künstler, A., Sauder, T., Unterfeld, C., & Stenzel, N. (2024, 9. Oktober). Illness Perceptions – Have we been underestimating the relevance of the factor in internalising disorders? – An evaluation of the psychometric properties of the German Illness Perception Questionnaire Mental Health (IPQ-MH) [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Langhammer, T., Unterfeld, C., Blankenburg, F., Erk, S., Fehm, L., Haynes, J.-D., Heinzel, S., Hilbert, K., Jacobi, F., Kathmann, N., Knaevelsrud, C., Renneberg, B., Ritter, K., Stenzel, N., Walter, H., & Lueken, U. (2024, 26. Juni). Towards precision psychotherapy for non-respondent patients: Design and methods of a naturalistic observational CBT-trial for single-case prediction with machine learning [Posterpräsentation]. Annual SPR Meeting, Ottawa, Kanada.

Langhammer, T., Blankenburg, F., Erk, S., Fehm, L., Haynes, J.-D., Heinzel, S., Hilbert, K., Jacobi, F., Kathmann, N., Knaevelsrud, C., Renneberg, B., Ritter, K., Stenzel, N., Walter, H., & Lueken, U. (2024, 9. Oktober). Towards Precision Psychotherapy for Non‐Respondent Patients: Recruitment Status and Descriptive Analysis of a Naturalistic Observational CBT Trial for Single‐Case Prediction with Machine Learning [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Tochadse, M., Gijsen, S., Rane, R. P., Lueken, U., Klawohn, J., Kathmann, N., & Ritter, K. (2024, 9. Oktober). BOLD variability and normative modelling feature construction for prediction in mental health [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Henze, G.-I., Giglberger, M., Bärtl, C., Konzok, J., Neidhart, M., Krause, T., Serin, E., Waller, L., Peter, H. L., Speicher, N., Kreuzpointner, L., Streit, F., Veer, I., Erk, S., Kirsch, P., Kudielka, B. M., Nichols, T. E., Wüst, S., & Walter, H. (2024, 9. Oktober). The Ups and Downs of Brain Stress: Testing the Triple Network Hypothesis in a Largescale Biopsychological Sample [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Hammelrath, L., Bimüller, G., Gas, B., Brose, A., & Knaevelsrud, C. (2024, 9. Oktober). Behind the spotlight: Using EMA and passive sensing to depict situational context in a clinical sample [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Sprengel, R., Jüres, F., Hajcak, G., Kathmann, N., & Klawohn, J. (2024, 23. Oktober). ELECTROPHYSIOLOGICAL MEASURES OF EMOTIONAL REACTIVITY AND EMOTION REGULATION IN HEALTHY INDIVIDUALS AND PATIENTS WITH INTERNALIZING DISORDERS [Posterpräsentation]. Annual Meeting of the Society for Psychophysiological Research, Prag, Tschechien.

Gijsen, S., & Ritter, K. (2024, 9. Oktober). Self-supervised learning for encoding pathological between-subject information in EEG data [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Unterfeld, C., Langhammer, T., Blankenburg, F., Erk, S., Fehm, L., Haynes, J., Heinzel, S., Hilbert, K., Jacobi, F., Kathmann, N., Knaevelsrud, C., Renneberg, B., Ritter, K. Stenzel, N., Walter, H., & Lueken, U. (2024, 9. Oktober). Towards Precision Psychotherapy for Non-Respondent Patients: Design and Methods of a Naturalistic Observational CBT Trial for Single-Case Prediction with Machine Learning [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Meinke, C., Hornstein, S., Schmidt, J., Arolt V., Dannlowski, U., Deckert, J., Domschke, K., Fehm, L., Fydrich, T., Gerlach, A. L., Hamm, A. O., Heinig, I., Hoyer, J., Kircher, T., Koelkebeck K., Lang, T., Margraf, J., Neudeck, P., Pauli, P., Richter, J., Rief, W., Schneider, S., Straube, B., Ströhle, A., Wittchen, H.-U., Zwanzger P., Walter, H., Lueken, U., Pittig, A., & Hilbert, K. (2024, 9. Oktober). Advancing the Personalized Advantage Index (PAI): A Systematic Review and Application in Two Large Multi-Site Samples in Anxiety Disorders [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Meinke, C., Wellan. S., Heinzel, S., Roesmann, K., Boehnlein, J., Gathmann, B., Herrmann, M. J., Junghoefer, M., Schwarzmeier, H., Seeger, F. R., Siminski, N., Straube, T., Dannlowski U., Leehr, E. J., Lueken, U., Walter, H., & Hilbert, K. (2024, 9. Oktober). Predicting treatment outcome based on baseline resting-state fMRI functional connectivity? A realistic view [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Jüres, F., Wewers, R., Hajcak, G., Kathmann, N., & Klawohn, J. (2024, 9. Oktober). Neural Correlates of Feedback Processing in Internalizing Disorders: A Comparison of Guessing and Learning Scenarios [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Gutmann, G. (2024, 9. Oktober). Decreased thalamic integration during distancing correlates with negative mood: A full-brain connectivity study in MDD using network-gppi [Posterpräsentation]. 5187 PREACT Symposium: Precision Psychotherapy Signatures, Predictions, & Clinical Utility, Berlin, Deutschland.

Wewers, R., Kathmann, N., Jüres, F., Klawohn, J. (2023, 27. September-1. Oktobter). Associations between emotion processing and self-reports of emotion regulation [Posterpräsentation]. Annual Meeting of the Society for Psychophysiological Research, New Orleans, USA.

Hammelrath, L., Heinrich, M., Burggraf, P., Schenk, H., & Knaevelsrud, C. (2023, 5. Juni). Tell me how I feel! Development of an Algorithm to Predict Depression Symptoms Based on Wearable Data [Poster presentation]. Society for Ambulatory Assessment, Amsterdam, Niederlande.

Meinke, C., Lueken, U., Walter, H., & Hilbert, K. (2023, 10.-13. Mai). Können Resting-State fMRT Konnektivität und maschinelles Lernen zur Prädiktion des individuellen Behandlungserfolgs genutzt werden? - Ein systematisches Review [Posterpräsentation]. 2. Deutscher Psychotherapie Kongress, Berlin, Deutschland.

Lueken, U. & FOR 5187 Konsortium (2023, 9.-13. Mai). Personalisierte Psychotherapie für Patient:innen mit fehlendem Behandlungserfolg: Wie können wir unsere Prädiktionsmodelle verbessern? [Konferenzbeitrag]. 2. Deutscher Psychotherapie Kongress (DPK), Berlin, Deutschland.

Wewers, R., Kathmann, N., Jüres, F., Klawohn, J. (2023, 8.-10. Juni). Associations between emotion processing and self-reports of emotion regulation [Posterpräsentation]. 48th Conference „Psychologie und Gehirn“, Tübingen, Deutschland.

Jüres, F., Wewers, R., Hajcak, G., Kathmann, N., & Klawohn, J. (2023, 27. September-1. Oktober). Comparing electrophysiological correlates of feedback processing across reward tasks: RewP and P300 in two paradigms [Posterpräsentation]. Annual Meeting of the Society for Psychophysiological Research, New Orleans, USA.

Jüres, F., Wewers, R., Hajcak, G., Kathmann, N., & Klawohn, J. (2023, 8.-10. Juni). Neural feedback processing during a guessing and a learning paradigm: Comparison of the RewP and the P300 across tasks [Posterpräsentation]. 48th Conference „Psychologie und Gehirn“, Tübingen, Deutschland.

Jüres, F., Elsner, B., Kaufmann, C., Kathmann, N., & Klawohn, J. (2023, 9.-13. Mai). Heart rate variability as a potential predictor for treatment outcome in patients with obsessive-compulsive disorder [Posterpräsentation]. 2. Deutscher Psychotherapie Kongress, Berlin, Deutschland.

Wellan, S., Daniels, A., & Walter, H. (2023, 20.-23. Juli). Neural correlates of hedonic functioning during pleasant touch [Posterpräsentation]. IPPA 2023, Vancouver, Kanada.

Wewers, R., Kathmann, N., Jüres, F., & Klawohn, J. (2023, 9. Mai). Associations between emotion processing and self-reports of emotion regulation [Posterpräsentation]. 2. Deutscher Psychotherapie Kongress, Berlin, Deutschland.

Lueken, U., Hilbert, K., Kathmann, N., Hahn, T., Straube, B., Kircher, T., Wittchen, H.-U., Dannlowski, U. (2022, 10.-15. September). Precision Psychotherapy: From signatures to predictions to clinical utility [Konferenzbeitrag]. 52nd Congress of the German Society of Psychology (DGPs), Hildesheim, Deutschland.

Leehr, E. J., Seeger, F. R., Böhnlein, J., Gathmann, B., Straube, T., Roesmann, K., Junghöfer, M., Schwarzmeier, H., Siminski, N., Herrmann, M. J., Langhammer, T., Goltermann, J., Grotegerd, D., Meinert, S., Winter, N. R., Dannlowski, U., & Lueken, U. (2024). Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia—A replication approach. Translational Psychiatry, 14(1), 137. https://doi.org/10.1038/s41398-024-02799-x

Hilbert, K., Boeken, O. J., Langhammer, T., Groenewold, N. A., Bas-Hoogendam, J. M., Aghajani, M., Zugman, A., Åhs, F., Arolt, V., Beesdo-Baum, K., Björkstrand, J., Blackford, J. U., Blanco-Hinojo, L., Böhnlein, J., Bülow, R., Cano, M., Cardoner, N., Caseras, X., Dannlowski, U., … Lueken, U. (2024). Cortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group. American Journal of Psychiatry, 181(8), 728–740. https://doi.org/10.1176/appi.ajp.20230032

Bruin, W. B., Zhutovsky, P., Van Wingen, G., Bas-Hoogendam, J. M., Groenewold, N. A., Hilbert, K., Winkler, A. M., Zugman, A., Agosta, F., Åhs, F., Andreescu, C., Antonacci, C., Asami, T., Assaf, M., Barber, J. P., Bauer, J., Bavdekar, S. Y., Beesdo‐Baum, K., Benedetti, F., . . . Aghajani, M. (2024). Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety Database using machine learning. Nature Mental Health, 2(1), 104–118. https://doi.org/10.1038/s44220-023-00173-2

Schulz, M., Bzdok, D., Haufe, S., Haynes, J. & Ritter, K. (2024). Performance reserves in brain-imaging-based phenotype prediction. Cell Reports, 43(1), 113597. https://doi.org/10.1016/j.celrep.2023.113597

Langhammer, T., Hilbert, K., Adolph, D., Arolt, V., Bischoff, S., Böhnlein, J., Cwik, J. C., Dannlowski, U., Deckert, J., Domschke, K., Evens, R., Fydrich, T., Gathmann, B., Hamm, A. O., Heinig, I., Herrmann, M. J., Hollandt, M., Junghoefer, M., Kircher, T., … Lueken, U. (2024). Resting-state functional connectivity in anxiety disorders: A multicenter fMRI study. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02768-2

Chavanne, A. V., Meinke, C., Langhammer, T., Roesmann, K., Boehnlein, J., Gathmann, B., Herrmann, M. J., Junghoefer, M., Klahn, L., Schwarzmeier, H., Seeger, F. R., Siminski, N., Straube, T., Dannlowski, U., Lueken, U., Leehr, E. J., & Hilbert, K. (2023). Individual-Level Prediction of Exposure Therapy Outcome Using Structural and Functional MRI Data in Spider Phobia: A Machine-Learning Study. Depression and Anxiety, 2023, 1–11. https://doi.org/10.1155/2023/8594273

Roesmann, K., Leehr, E. J., Böhnlein, J., Gathmann, B., Herrmann, M. J., Junghöfer, M., Schwarzmeier, H., … & Lueken, U. (2023). Mechanisms of action underlying virtual reality exposure treatment in spider phobia: pivotal role of within-session fear reduction. Journal of Anxiety Disorders, 102790. 10.1016/j.janxdis.2023.102790

Groenewold, N. A., Bas-Hoogendam, J.-M., Amod, A. R., Laansma, M. A., Van Velzen, L. S., Aghajani, M., Hilbert, K., … Lueken, U., … & Van der Wee, N. J. A. (2023). Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Molecular Psychiatry, 28, 1079-1089. 10.1038/s41380-022-01933-9

Rane, R. P., Musial, M. P. M., Beck, A. M., Rapp, M. A., Schlagenhauf, F., Banaschewski, T., Bokde, A. L., Martinot, M. P., Artiges, É., Nees, F., Lemaître, H., Hohmann, S., Schümann, G., Walter, H., Heinz, A. & Ritter, K. (2023). Uncontrolled eating and sensation-seeking partially explain the prediction of future binge drinking from adolescent brain structure. NeuroImage: Clinical, 40, 103520. https://doi.org/10.1016/j.nicl.2023.103520

Rane, R. P., De Man, E. F., Kim, J., Görgen, K., Tschorn, M., Rapp, M. A., Banaschewski, T., Bokde, A. L., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Brühl, R., Martinot, J., Martinot, M. P., Artiges, É., Nees, F., Papadopoulos, D., . . . Ritter, K. (2022). Structural differences in adolescent brains can predict alcohol misuse. eLife, 11. https://doi.org/10.7554/elife.77545